Engineering Novel TNFα-armed Oncolytic Viruses for Combination Immunotherapy with SMAC Mimetics

Engineering Novel TNFα-armed Oncolytic Viruses for Combination Immunotherapy with SMAC Mimetics

Small molecular Inhibitor of Apoptosis (IAP) antagonists, known as Smac mimetic compounds (SMCs), are a novel class of anti-cancer drugs currently undergoing clinical trials. SMCs were designed to mimic the function of the pro-apoptotic protein, Smac, which directly depletes cells of cIAP1 and cIAP2...

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Bibliographic Details
Main Author:	Pichette, Stephanie
Other Authors:	Korneluk, Robert
Language:	en
Published:	Université d'Ottawa / University of Ottawa 2016
Subjects:	Cancer Immunotherapy Smac mimetics Oncolytic virus Vascular shutdwown TNFα
Online Access:	http://hdl.handle.net/10393/35513 http://dx.doi.org/10.20381/ruor-471

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