Sortilin is a Negative Regulator of Sonic Hedgehog Processing and Anterograde Trafficking in Neurons
Sonic Hedgehog (SHH) is a secreted morphogen that is an essential regulator of patterning and growth. The SHH protein requires cleavage of its full-length precursor (SHHFL) for secretion of biologically active SHH (SHHNp). Mutations in SHH that affect SHH processing are associated with human disease...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2016
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| Online Access: | http://hdl.handle.net/10393/34560 http://dx.doi.org/10.20381/ruor-5745 |