Expression Levels of E-cadherin in Breast Cancer Cells Alter Apoptotic Susceptibility and Facilitate Cancer Stem Cell Phenotypes in Response to Wnt Signalling
It is well established that the Wnt pathway is associated with tumorigenesis in a wide range of human cancers, including a majority of breast cancers. However, due to diverse roles of Wnt signalling, therapeutic targeting has not yielded consistent results and underlying mechanisms remain unclear. H...
Main Author: | Ooi, Sarah |
---|---|
Other Authors: | Wang, Lisheng |
Language: | en |
Published: |
Université d'Ottawa / University of Ottawa
2015
|
Subjects: | |
Online Access: | http://hdl.handle.net/10393/32961 http://dx.doi.org/10.20381/ruor-1490 |
Similar Items
-
Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer
by: Pamungkas Bagus Satriyo, et al.
Published: (2019-01-01) -
MicroRNA-638 inhibits the progression of breast cancer through targeting HOXA9 and suppressing Wnt/β-cadherin pathway
by: Qian Xu, et al.
Published: (2021-08-01) -
Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells
by: Nicola Bougen-Zhukov, et al.
Published: (2019-09-01) -
The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer
by: Alexandros Drivalos, et al.
Published: (2011-06-01) -
Wnt Signaling in Cancer Stem Cell Biology
by: Felipe de Sousa e Melo, et al.
Published: (2016-06-01)