The Smn-Independent Beneficial Effects of Trichostatin A on an Intermediate Mouse Model of Spinal Muscular Atrophy

The Smn-Independent Beneficial Effects of Trichostatin A on an Intermediate Mouse Model of Spinal Muscular Atrophy

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Trichostatin A (TSA) is a histone deacetylase inhibitor with beneficial effects in spinal muscular atrophy mouse models that carry the human SMN2 transgene. Whether TSA specifically targets the upregulation of the SMN2 gene or whether other genes respond to TSA and in turn provide neuroprotection in...

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Bibliographic Details
Main Author: Yazdani, Armin A.
Other Authors: Kothary, Rashmi
Language:en
Published: Université d'Ottawa / University of Ottawa 2014
Subjects:
Motor neuron disease
Spinal muscular atrophy
Survival motor neuron
Trichostatin A
Therapeutics
HDAC inhibitor
Online Access:http://hdl.handle.net/10393/30703
http://dx.doi.org/10.20381/ruor-3597

Internet

http://hdl.handle.net/10393/30703
http://dx.doi.org/10.20381/ruor-3597

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