The Effects of Dilated Cardiomyopathy and Atrial Fibrillation Lamin A/C Mutations on Phosphorylated Kinase C Alpha Cellular Distribution and Activity
Dilated Cardiomyopathy (DCM) with conduction disease and Atrial Fibrillation (AF) are the two cardiac-specific diseases associated with lamin A/C gene (LMNA) mutations. Protein Kinase C Alpha, (PKCα) functions as a nodal integrator of cardiac contractility by “sensing” intracellular calcium and sign...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2014
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| Online Access: | http://hdl.handle.net/10393/30545 http://dx.doi.org/10.20381/ruor-6688 |