The Role and Regulation of the Phosphatase PPM1D in Chemoresistant Gynecological Cancers

The Role and Regulation of the Phosphatase PPM1D in Chemoresistant Gynecological Cancers

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Cisplatin (CDDP; cis-diamminedichloroplatinum) resistance presents a major impediment in the treatment of several gynecologic solid tumors, including ovarian and cervical tumors. p53, a critical regulator of cellular apoptosis, is a determinant of CDDP sensitivity. In our study, we have observed tha...

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Bibliographic Details
Main Author: Ali, Ahmed Y.
Other Authors: Tsang, Benjamin
Language:en
Published: Université d'Ottawa / University of Ottawa 2014
Subjects:
Gynecological cancers
Cisplatin chemoresistance
PPM1D
p53
Akt
Online Access:http://hdl.handle.net/10393/30489
http://dx.doi.org/10.20381/ruor-3512

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