Phosphatidylcholine Metabolism and ACAT Affect the Trafficking of LDL-derived Free Cholesterol in Cholesterol-loaded CHO Cells

Phosphatidylcholine Metabolism and ACAT Affect the Trafficking of LDL-derived Free Cholesterol in Cholesterol-loaded CHO Cells

Show other versions (2)

In vitro studies have shown that the major membrane phospholipid phosphatidylcholine (PC) can positively influence the incorporation of cholesterol in lipid membranes. The influence of PC on the cellular trafficking of LDL-derived free cholesterol was investigated. Sterol regulatory-defective (SRD)-...

Full description

Bibliographic Details
Main Author:	Landry, Chandra
Other Authors:	Lagace, Thomas
Language:	en
Published:	Université d'Ottawa / University of Ottawa 2012
Subjects:	Cholesterol Filipin NPC1 LDLR Phosphatitylcholine Lysosomal Loading Lipid Droplet
Online Access:	http://hdl.handle.net/10393/23087 http://dx.doi.org/10.20381/ruor-5892

Similar Items

Phosphatidylcholine Metabolism and ACAT Affect the Trafficking of LDL-derived Free Cholesterol in Cholesterol-loaded CHO Cells
by: Landry, Chandra
Published: (2012)

Phosphatidylcholine Metabolism and ACAT Affect the Trafficking of LDL-derived Free Cholesterol in Cholesterol-loaded CHO Cells
by: Landry, Chandra
Published: (2012)

Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disorders
by: Jarmila Králová, et al.
Published: (2018-09-01)

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer
by: Junfang Lyu, et al.
Published: (2019-04-01)

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells
by: Nina H. Pipalia, et al.
Published: (2006-02-01)

Adenylyl cyclase 1 as a major isoform to generate cAMP signaling for apoA-1-mediated cholesterol efflux pathway
by: Wanze Tang, et al.
Published: (2018-04-01)

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
by: Leslie A McCauliff, et al.
Published: (2019-10-01)

Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)
by: Dyonne Y. Vos, et al.
Published: (2021-08-01)

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
by: Michael Nguyen Trinh, et al.
Published: (2018-07-01)

Influence of cholesterol on cancer progression and therapy
by: Shyamananda Singh Mayengbam, et al.
Published: (2021-06-01)

MiR-1908 Is a Cholesterol Responsive MicroRNA Implicated In Cholesterol Regulation
by: Beehler, Kaitlyn
Published: (2020)

Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System
by: Kexin Zhao, et al.
Published: (2017-05-01)

6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells
by: Xiao Li, et al.
Published: (2018-02-01)

Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution[S]
by: Reiko Ishitsuka, et al.
Published: (2011-11-01)

Targeting Cholesterol Metabolism as Efficient Antiviral Strategy Against the Hepatitis E VirusSummary
by: Mirco Glitscher, et al.
Published: (2021-01-01)

Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation
by: Marion Willenborg, et al.
Published: (2005-12-01)

Deregulation of signalling in genetic conditions affecting the lysosomal metabolism of cholesterol and galactosyl-sphingolipids
by: S. Gowrishankar, et al.
Published: (2020-12-01)

Cellular cholesterol efflux and cholesterol loading capacity of serum: effects of LDL-apheresis
by: M.P. Adorni, et al.
Published: (2012-05-01)

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol[S]
by: Xuewei Zhu, et al.
Published: (2010-11-01)

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
by: Fabian Arenas, et al.
Published: (2017-11-01)

A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model
by: Hong Yu Wang, et al.
Published: (2016-07-01)

Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells
by: Nina H. Pipalia, et al.
Published: (2017-04-01)

Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice
by: Patrick C. Reid, et al.
Published: (2003-05-01)

Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI
by: Patricia G. Yancey, et al.
Published: (2007-05-01)

Cardiovascular mortality after intensive LDL-Cholesterol lowering: Does baseline LDL-Cholesterol really matter?
by: Safi U. Khan, et al.
Published: (2020-03-01)

Prevalence and Impact of Apolipoprotein E7 on LDL Cholesterol Among Patients With Familial Hypercholesterolemia
by: Hayato Tada, et al.
Published: (2021-04-01)

Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export
by: Jian Li, et al.
Published: (2016-09-01)

Hepatic expression of cholesterol regulating genes favour increased circulating low-density lipoprotein in HIV infected patients with gallstone disease: a preliminary study
by: Suman Mewa Kinoo, et al.
Published: (2021-03-01)

The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor
by: Matyas, Angela
Published: (2020)

Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux
by: Patricia G. Yancey, et al.
Published: (2001-03-01)

Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence[S]
by: Masaki Igarashi, et al.
Published: (2010-02-01)

Description of Discordance Between LDL Cholesterol, Non-HDL Cholesterol, and LDL Particle Number Among Patients of a Lipid Clinic
by: Joshua W Gaborcik, et al.
Published: (2017-09-01)

LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway
by: Ziye Chen, et al.
Published: (2021-09-01)

PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation
by: Aureli Luquero, et al.
Published: (2021-03-01)

Catalysis of ACAT may be completed within the plane of the membrane: a working hypothesis
by: Ta Yuan Chang, et al.
Published: (2001-12-01)

Organelle dysfunction modulates cholesterol biosynthesis pathway
by: Pereyra, Leonardo Gabriel
Published: (2019)

Sulforaphane inhibits hepatic steatosis in rats by down-regulating DGAT2 and ACAT1 expression
by: TIAN Sicong, et al.
Published: (2019-06-01)

GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice
by: Martijn J. C. van der Lienden, et al.
Published: (2021-03-01)

Regulation of Lipid Droplet Cholesterol Efflux from Macrophage Foam Cells: a Role for Oxysterols and Autophagy
by: Ouimet, Mireille
Published: (2011)

Regulation of Lipid Droplet Cholesterol Efflux from Macrophage Foam Cells: a Role for Oxysterols and Autophagy
by: Ouimet, Mireille
Published: (2011)