The Role of the Central Region of the Third Intracellular Loop of D1-Class Receptors in Signalling

The Role of the Central Region of the Third Intracellular Loop of D1-Class Receptors in Signalling

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The D1-class receptors (D1R, D5R) each possess distinct signaling characteristics; however, pharmacological selectivity between them remains elusive. The third intracellular loops (IL3) of D1R and D5R harbour divergent residues that may contribute to their individual signalling phenotypes. Here we...

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Bibliographic Details
Main Author: Charrette, Andrew
Other Authors: Tiberi, Mario
Language:en
Published: Université d'Ottawa / University of Ottawa 2012
Subjects:
G protein-coupled receptor
GPCR
Dopamine
D1
D5
homology model
deletion
third intracellular loop
D1-class receptor
Online Access:http://hdl.handle.net/10393/23080
http://dx.doi.org/10.20381/ruor-5875

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