Impaired IL-7 / IL-7Ralpha Signaling in HIV Infection: Role of the Transcriptional Repressor GFI1 in Suppressing IL-7Ralpha Expression and Driving the Proliferation of Human CD8 T Lymphocytes

Impaired IL-7 / IL-7Ralpha Signaling in HIV Infection: Role of the Transcriptional Repressor GFI1 in Suppressing IL-7Ralpha Expression and Driving the Proliferation of Human CD8 T Lymphocytes

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Cytotoxic CD8 T lymphocytes kill virus-infected cells and are critical for viral clearance from the body. Cytokines, particularly those sharing the common gamma receptor chain (gamma c), play a key role in this cytotoxic function as well as in the growth, differentiation and homeostasis of CD8 T lym...

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Bibliographic Details
Main Author: Benoit, Anita C.
Other Authors: Kryworuchko, Marko
Language:en
Published: Université d'Ottawa / University of Ottawa 2011
Subjects:
HIV
GFI1
IL-7Ralpha
CD8 T lymphocytes
Online Access:http://hdl.handle.net/10393/19732
http://dx.doi.org/10.20381/ruor-4401
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