Impaired IL-7 / IL-7Ralpha Signaling in HIV Infection: Role of the Transcriptional Repressor GFI1 in Suppressing IL-7Ralpha Expression and Driving the Proliferation of Human CD8 T Lymphocytes
Cytotoxic CD8 T lymphocytes kill virus-infected cells and are critical for viral clearance from the body. Cytokines, particularly those sharing the common gamma receptor chain (gamma c), play a key role in this cytotoxic function as well as in the growth, differentiation and homeostasis of CD8 T lym...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2011
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| Online Access: | http://hdl.handle.net/10393/19732 http://dx.doi.org/10.20381/ruor-4401 |