Effects of Daily Oral Injections of Quercetin on Implanted Colon-25 Tumor Growth in Balb-C Mice

• Main Author: Hayashi, Adam
• Other Authors: Lott, James R.
• Format: Others
• Language: English
• Published: University of North Texas 2000
• Subjects: Quercetin.; Cancer > Chemotherapy.; Mice > Diseases > Chemotherapy.; bioflavonoids; mammalian tumors
• Online Access: https://digital.library.unt.edu/ark:/67531/metadc2525/

The effects of three oral dosages (0.4 mg, 0.8 mg, and 1.6 mg) of quercetin on Colon-25 tumors implanted in Balb-c mice were studied. The data in this study show that: (1) certain dosages of quercetin in alcohol solutions, reduces the weight, and size of implanted Colon-25 tumors in Balb-c mice, (2) these same dosages of quercetin all produce a profound neutrophilia combined with a significant lymphopenia at day 20 post-implantation, and (3) there was relatively little evidence of histological changes in the quercetin-treated tumor section which would indicate that the action(s) of quercetin is primarily at the subcellular level probably within the nuclei of the tumor cells.