Studies on formation and stabilization of pathological thrombi in vivo
Platelet activation and adhesion resulting in thrombus growth is essential for normal hemostasis, but can lead to irreversible, life-threatening vessel occlusion. In the current study, the contribution of platelet integrins, activation receptors and the contact system of blood coagulation in such pa...
| Main Author: | |
|---|---|
| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
2005
|
| Subjects: | |
| Online Access: | https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/1437 http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-16784 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-16784 https://opus.bibliothek.uni-wuerzburg.de/files/1437/dissertation.pdf |
| Summary: | Platelet activation and adhesion resulting in thrombus growth is essential for normal hemostasis, but can lead to irreversible, life-threatening vessel occlusion. In the current study, the contribution of platelet integrins, activation receptors and the contact system of blood coagulation in such pathological conditions was investigated in mice. === Plättchenaktivierung, -adhäsion und nachfolgende Thrombusbildung ist ein für die Hämostase essentieller Prozess, der jedoch zu irreversiblem lebensbedrohlichen Gefäßverschluss führen kann. In der vorliegenden Arbeit wurde die Rolle von Thrombozyten-Integrinen, aktivierenden Rezeptoren, sowie dem Kontaktsystem der Koagulation unter pathologischen Bedingungen im Maussystem untersucht. |
|---|