Computational methods for assessing drug-target residence times in bacterial enoyl-ACP reductases and predicting small-molecule permeability for the \(Mycobacterium\) \(tuberculosis\) cell wall
\textbf{Molecular Determinants of Drug-Target Residence Times of Bacterial Enoyl-ACP Reductases.} Whereas optimization processes of early drug discovery campaigns are often affinity-driven, the drug-target residence time $t_R$ should also be considered due to an often strong correlation with \textit...
| Main Author: | |
|---|---|
| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12738 http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-127386 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-127386 https://opus.bibliothek.uni-wuerzburg.de/files/12738/Dissertation_Merget.pdf https://opus.bibliothek.uni-wuerzburg.de/files/12738/Dissertation_Merget_small.pdf |
Internet
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12738http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-127386
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-127386
https://opus.bibliothek.uni-wuerzburg.de/files/12738/Dissertation_Merget.pdf
https://opus.bibliothek.uni-wuerzburg.de/files/12738/Dissertation_Merget_small.pdf