The role of the cytoskeleton in platelet production and the pathogenesis of platelet disorders in humans and mice
Platelets are continuously produced from megakaryocytes (MK) in the bone marrow by a cytoskeleton-driven process of which the molecular regulation is not fully understood. As revealed in this thesis, MK/ platelet-specific Profilin1 (Pfn1) deficiency results in micro- thrombocytopenia, a hallmark of...
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| Format: | Doctoral Thesis |
| Language: | English |
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2017
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| Online Access: | https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/12266 http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-122662 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-122662 https://opus.bibliothek.uni-wuerzburg.de/files/12266/Stritt_cytoskeleton_platelet_production.pdf |