NaV1.5 Modulation: From Ionic Channels to Cardiac Conduction and Substrate Heterogeneity

NaV1.5 Modulation: From Ionic Channels to Cardiac Conduction and Substrate Heterogeneity

Bibliographic Details
Main Author:	Raad, Nour
Other Authors:	Luther, Stefan Prof. Dr.
Format:	Doctoral Thesis
Language:	English
Published:	2014
Subjects:	571.4 Antiarrhythmic drugs Optical Mapping Action potential duration Spatial dispersion of repolarization Cardiac depolarization Conduction velocity Anisotropy Duchenne muscular dystrophy mdx - mouse model Dystrophin ΔKPQ mouse model Long QT Syndrome 3 Cardiac Sodium Channel (NaV1.5) Flecainide Maximum upstroke velocity Least Squares Ellipsis Fitting Method Area Fitting Method Plane Fitting Method Conduction abnormalities Voltage sensitive dyes Cardiac arrhythmia Functional heterogeneity Spatial-temporal heterogeneity Proarrhythmia Activation maps Symmetry breaking Intrinsic cardiac heterogeneity Biologie (PPN619462639)
Online Access:	http://hdl.handle.net/11858/00-1735-0000-0022-5E72-F http://nbn-resolving.de/urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5E72-F-2

Similar Items

Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models
by: Lois Choy, et al.
Published: (2016-09-01)

Transgenic Rabbit Models in Proarrhythmia Research
by: István Baczkó, et al.
Published: (2020-06-01)

How to measure propagation velocity in cardiac tissue: a simulation study
by: Andre C. Linnenbank, et al.
Published: (2014-07-01)

Examination of the Effects of Conduction Slowing on the Upstroke of Optically Recorded Action Potentials
by: Christopher O’Shea, et al.
Published: (2019-10-01)

T‐wave heterogeneity in standard resting 12‐lead ECGs is associated with 90‐day cardiac mortality in women following emergency department admission: A nested case–control study
by: Felipe R. Monteiro, et al.
Published: (2021-05-01)

Body Surface Mapping of Ventricular Repolarization Heterogeneity: An Ex-vivo Multiparameter Study
by: Marianna Meo, et al.
Published: (2020-08-01)

What is the arrhythmic substrate in viral myocarditis? Insights from clinical and animal studies
by: Gary Tse, et al.
Published: (2016-07-01)

Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction
by: Aparna C. Sankarankutty, et al.
Published: (2021-10-01)

Electrophysiological and structural determinants of electrotonic modulation of repolarization by the activation sequence
by: Walton, R.D., et al.
Published: (2018)

Trabecular Architecture Determines Impulse Propagation Through the Early Embryonic Mouse Heart
by: Veronika Olejníčková, et al.
Published: (2019-01-01)

High-Resolution Measurement of Local Activation Time Differences From Bipolar Electrogram Amplitude
by: Stephen Gaeta, et al.
Published: (2021-04-01)

Epicardial mapping and ablation of the right ventricle substrate during flecainide testing in Brugada syndrome
by: Laila Gonzalez-Melchor, MD, et al.
Published: (2016-01-01)

Exploring Dystrophin-Mediated Control of Neural Stem Cell Fate Associated with Intellectual Disability In Duchenne Muscular Dystrophy Patients
by: Thompson, Shannon
Published: (2018)

Arrhythmogenic Mechanisms in Hypokalaemia: Insights From Pre-clinical Models
by: Gary Tse, et al.
Published: (2021-02-01)

QT interval – Its measurement and clinical significance
by: Sita Ram Mittal
Published: (2019-01-01)

Electrophysiological and structural determinants of electrotonic modulation of repolarization by the activation sequence
by: Richard David Walton, et al.
Published: (2013-10-01)

GRMD cardiac and skeletal muscle metabolism gene profiles are distinct
by: Larry W. Markham, et al.
Published: (2017-04-01)

Different habitus but similar electrocardiogram: Cardiac repolarization parameters in children – Comparison of elite athletes to obese children
by: Christian Paech, et al.
Published: (2019-01-01)

Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study
by: Eriko Yamanaka, et al.
Published: (2019-11-01)

Indices of Defective Autophagy in Whole Muscle and Lysosome Enriched Fractions From Aged D2-mdx Mice
by: Swathy Krishna, et al.
Published: (2021-07-01)

The effect of a novel dual-task exercise program for balance, mobility, gaze, and cognition skills in community dwelling older adults: A pilot study
by: Alhasani, Rehab
Published: (2015)

Analyzing the Role of Repolarization Gradients in Post-infarct Ventricular Tachycardia Dynamics Using Patient-Specific Computational Heart Models
by: Eric Sung, et al.
Published: (2021-09-01)

Absence of Rgs5 Influences the Spatial and Temporal Fluctuation of Cardiac Repolarization in Mice
by: Zi-liang Song, et al.
Published: (2021-03-01)

The Amplitude-Normalized Area of a Bipolar Electrogram as a Measure of Local Conduction Delay in the Heart
by: Caroline Mendonca Costa, et al.
Published: (2020-05-01)

Electrophysiological mechanisms of long and short QT syndromes
by: Gary Tse, et al.
Published: (2017-03-01)

Optical Electrophysiology in the Developing Heart
by: Kandace Thomas, et al.
Published: (2018-05-01)

Connexin diversity in the heart: insights from transgenic mouse models
by: Sander eVerheule, et al.
Published: (2013-06-01)

Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes
by: Jan Pavel Kucera, et al.
Published: (2015-09-01)

Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
by: Piccirillo G, et al.
Published: (2013-03-01)

Increase in Tpeak–Tend interval induced by cardiac resynchronization therapy is a predictor of ventricular tachyarrhythmia
by: Fumito Miyoshi, et al.
Published: (2012-08-01)

Lineages of the Cardiac Conduction System
by: Rajiv Mohan, et al.
Published: (2017-05-01)

Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes
by: Rachel E. Caves, PhD, et al.
Published: (2020-08-01)

Long-Term Efficacy of Systemic Multiexon Skipping Targeting Dystrophin Exons 45–55 With a Cocktail of Vivo-Morpholinos in Mdx52 Mice
by: Yusuke Echigoya, et al.
Published: (2015-01-01)

Analysis of 24-h Rhythm in Ventricular Repolarization Identifies QT Diurnality As a Novel Clinical Parameter Associated with Previous Ventricular Arrhythmias in Heart Failure Patients
by: Bastiaan C. Du Pre, et al.
Published: (2017-08-01)

Estimating refractory periods during atrial fibrillation based on electrogram cycle lengths in a heterogeneous simulation setup
by: Unger Laura, et al.
Published: (2017-09-01)

Assessment of the prognostic utility of the FIT treadmill score in coronary artery disease patients undergoing cardiac rehabilitation
by: Lucky R. Cuenza, et al.
Published: (2019-03-01)

Editorial: Perspectives of Antiarrhythmic Drug Therapy: Disappointing Past, Current Efforts, and Faint Hopes
by: Péter P. Nánási, et al.
Published: (2020-07-01)

Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity
by: Richard Ang, et al.
Published: (2020-03-01)

Electrophysiological Effects of Extracellular Vesicles Secreted by Cardiosphere-Derived Cells: Unraveling the Antiarrhythmic Properties of Cell Therapies
by: Lidia Gómez-Cid, et al.
Published: (2020-08-01)

Upstroke Time Per Cardiac Cycle as A Novel Parameter for Mortality Prediction in Patients with Acute Myocardial Infarction
by: Po-Chao Hsu, et al.
Published: (2020-03-01)