Mutagénèse semi-aléatoire au site actif de la DHFR humaine : création et caractérisation de variantes hautement résistantes au MTX

Mutagénèse semi-aléatoire au site actif de la DHFR humaine : création et caractérisation de variantes hautement résistantes au MTX

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Bibliographic Details
Main Author:	Volpato, Jordan
Other Authors:	Pelletier, Joelle
Published:	2009
Subjects:	Dihydrofolate réductase humaine Human dihydrofolate reductase Catalyse enzymatique Enzyme catalysis Inhibition Métabolisme du folate Folate metabolism Mutagénèse combinatoire Combinatorial mutagenesis Résistance aux antifolates Antifolate resistance Méthotrexate Methotrexate Marqueurs de sélection Selectable markers Cellules hematopoïétiques Hematopoietic cells Cristallographie aux rayons X X-ray crystallography Chemistry - Biochemistry / Chimie - Biochimie (UMI : 0487)
Online Access:	http://hdl.handle.net/1866/2895

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