Nanoparticules lipidiques pH-sensibles basées sur une bascule moléculaire pour la délivrance intracytoplasmique de siRNA

Nanoparticules lipidiques pH-sensibles basées sur une bascule moléculaire pour la délivrance intracytoplasmique de siRNA

La délivrance intracytoplasmique de petites molécules hydrophiles et de gènes (ADN, ARN) est un défi majeur pour l’industrie pharmaceutique, puisque ces composés sont incapables de franchir les membranes biologiques par eux-mêmes. L’utilisation de nanovecteurs lipidiques permet de surmonter les étap...

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Bibliographic Details
Main Author:	Viricel, Warren
Other Authors:	Leblond Chain, Jeanne
Language:	fr
Published:	2017
Subjects:	Lipides pH-sensibilité Bascule moléculaire Thérapie génique Liposomes Nanoparticules lipidiques Echappement endosomal Délivrance de drogues Délivrance de siRNA Lipids pH-sensitive Molecular switch Gene therapy Lipid nanoparticles Endosomal escape Drug delivery siRNA delivery siRNA Chemistry - Pharmaceutical / Chimie pharmaceutique (UMI : 0491)
Online Access:	http://hdl.handle.net/1866/18594

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