Adapting the EMPIRIC Approach to Investigate Evolutionary Constraints in Influenza A Virus Surface Proteins

Adapting the EMPIRIC Approach to Investigate Evolutionary Constraints in Influenza A Virus Surface Proteins

Controlling influenza A virus (IAV) infections remains a challenge largely due to the high replication and mutation rates of the virus. IAV is a negative-sense RNA virus with two main surface proteins — hemagglutinin (HA) and neuraminidase (NA). HA recognizes and binds sialic acid on host cell recep...

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Bibliographic Details
Main Author: Canale, Aneth S.
Format: Others
Published: eScholarship@UMMS 2017
Subjects:
Molecular evolution
deep mutational scanning
hemagglutinin
influenza
fitness
Biochemistry
Biophysics
Other Ecology and Evolutionary Biology
Structural Biology
Online Access:https://escholarship.umassmed.edu/gsbs_diss/948
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1954&context=gsbs_diss

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