The Structural Basis for the Interdependence of Drug Resistance in the HIV-1 Protease
The human immunodeficiency virus type 1 (HIV-1) protease (PR) is a critical drug target as it is responsible for virion maturation. Mutations within the active site (1°) of the PR directly interfere with inhibitor binding while mutations distal to the active site (2°) to restore enzymatic fitness. I...
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| Format: | Others |
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eScholarship@UMMS
2016
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/879 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1881&context=gsbs_diss |