The Structural Basis for the Interdependence of Drug Resistance in the HIV-1 Protease

The Structural Basis for the Interdependence of Drug Resistance in the HIV-1 Protease

The human immunodeficiency virus type 1 (HIV-1) protease (PR) is a critical drug target as it is responsible for virion maturation. Mutations within the active site (1°) of the PR directly interfere with inhibitor binding while mutations distal to the active site (2°) to restore enzymatic fitness. I...

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Bibliographic Details
Main Author: Ragland, Debra A.
Format: Others
Published: eScholarship@UMMS 2016
Subjects:
HIV-1
Protease
Drug Resistance
Compensatory Mutations
Accessory Mutations
Secondary Mutations
Peripheral Mutations
AIDS
Computational Biology
Statistics
Machine Learning
Molecular Dynamics Simulations
Crystallography
Algebra
Applied Statistics
Biochemistry
Biophysics
Biostatistics
Statistical Theory
Structural Biology
Theory and Algorithms
Online Access:https://escholarship.umassmed.edu/gsbs_diss/879
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1881&context=gsbs_diss

Internet

https://escholarship.umassmed.edu/gsbs_diss/879
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1881&context=gsbs_diss

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