Upregulation of Heme Pathway Enzyme ALA Synthase-1 by Glutethimide and 4,6-Dioxoheptanoic Acid and Downregulation by Glucose and Heme: A Dissertation

Upregulation of Heme Pathway Enzyme ALA Synthase-1 by Glutethimide and 4,6-Dioxoheptanoic Acid and Downregulation by Glucose and Heme: A Dissertation

5-Aminolevulinic acid synthase-1 (ALAS-1) is the first and normally rate-controlling enzyme for hepatic heme biosynthesis. ALAS-1 is highly inducible, especially in liver, in response to changes in nutritional status, and to drugs that induce cytochrome P-450. The critical biochemical abnormality of...

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Bibliographic Details
Main Author: Kolluri, Sridevi
Format: Others
Published: eScholarship@UMMS 2004
Subjects:
5-Aminolevulinate Synthetase
Down-Regulation
Enzyme Induction
Enzyme Inhibitors
Glutethimide
Heme
Heptanoic Acids
Liver
Up-Regulation
Digestive System
Enzymes and Coenzymes
Nutritional and Metabolic Diseases
Organic Chemicals
Online Access:https://escholarship.umassmed.edu/gsbs_diss/121
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1121&context=gsbs_diss

Internet

https://escholarship.umassmed.edu/gsbs_diss/121
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1121&context=gsbs_diss

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