DNA damage and disruption of cellular bioenergetics contribute to the anti-cancer effects of pharmacological ascorbate
The clinical potential of pharmacological ascorbate (P-AscH-; IV delivery achieving mM concentrations in blood) as an adjuvant in cancer therapy is being re-evaluated. At mM concentrations, P-AscH- is thought to exhibit anti-cancer activity via generation of a flux of H2O2 in tumors, which leads to...
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| Format: | Others |
| Language: | English |
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University of Iowa
2018
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| Online Access: | https://ir.uiowa.edu/etd/6551 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=8050&context=etd |