Testing intermediates to unravel the mechanism of flavin-dependent thymidylate biosynthesis
In humans and most eukaryotes, thymidylate synthase (TSase) serves as a key enzyme that catalyzes the reductive methylation of deoxyuridine monophosphate (dUMP) to synthesize deoxythymidine monophosphate (dTMP), a key component of DNA. The N5, N10- methylene-5,6,7,8-tetrahydrofolate (MTHF) serves as...
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| Format: | Others |
| Language: | English |
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University of Iowa
2018
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| Online Access: | https://ir.uiowa.edu/etd/6478 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=7978&context=etd |