Synthesis of carboxyphosphonates and bisphosphonates as potential GGTase II and GGDPS inhibitors
Inhibition of enzymes in the isoprenoid biosynthetic pathway (IBP) plays an important role in the treatment of bone diseases and lowering cholesterol. The IBP begins with the enzyme HMG-CoA reductase catalyzing the conversion of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid. Mevalonic a...
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| Language: | English |
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University of Iowa
2018
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| Online Access: | https://ir.uiowa.edu/etd/6201 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=7533&context=etd |