Synthesis of carboxyphosphonates and bisphosphonates as potential GGTase II and GGDPS inhibitors

Synthesis of carboxyphosphonates and bisphosphonates as potential GGTase II and GGDPS inhibitors

Inhibition of enzymes in the isoprenoid biosynthetic pathway (IBP) plays an important role in the treatment of bone diseases and lowering cholesterol. The IBP begins with the enzyme HMG-CoA reductase catalyzing the conversion of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid. Mevalonic a...

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Bibliographic Details
Main Author: Matthiesen, Robert Armin
Other Authors: Wiemer, David F.
Format: Others
Language:English
Published: University of Iowa 2018
Subjects:
Bisphosphonates
Carboxyphosphonates
Click Chemistry
Geranyl geranyl diphosphate synthase
Phosphorus Chemistry
Chemistry
Online Access:https://ir.uiowa.edu/etd/6201
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=7533&context=etd

Internet

https://ir.uiowa.edu/etd/6201
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=7533&context=etd

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