FHIT inactivation combined with cigarette smoke enhances the oxidative stress response
The FHIT gene is located on the most fragile site in the human genome. FHIT gene deletions are among the earliest and most frequent events in carcinogenesis, particularly in carcinogen-exposed tissue. Previous work in mouse and cell culture models established FHIT to be an authentic tumor suppressor...
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| Language: | English |
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University of Iowa
2013
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| Online Access: | https://ir.uiowa.edu/etd/1295 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=5334&context=etd |