Studies of the Rev1 protein and its role in the replication of damaged DNA
Sites of unrepaired DNA damage block DNA synthesis by replicative polymerases and interrupt replication fork progression. This is a problem because stalled replication forks can collapse leading to DNA double-stranded breaks, chromosome instability, and eventually cell death. The translesion DNA syn...
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| Format: | Others |
| Language: | English |
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University of Iowa
2012
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| Online Access: | https://ir.uiowa.edu/etd/5044 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=5044&context=etd |