Function of Replication Protein A in DNA repair and cell checkpoints
Replication Protein A (RPA), the major eukaryotic single-strand DNA (ssDNA) binding protein, is essential for replication, repair, recombination, and checkpoint activation. Defects in RPA-associated cellular activities lead to genomic instability, a major factor in the pathogenesis of cancer. The ss...
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| Language: | English |
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University of Iowa
2012
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| Online Access: | https://ir.uiowa.edu/etd/2515 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=4644&context=etd |