DNA breaks regulate neuronal activity: NMDA-receptor and ionizing radiation-mediated DNA double-strand breaks govern activity regulating early-response gene expression
DNA (Deoxyribonucleic acid) double-strand breaks (DSBs) are the hazardous form of DNA damage endured on multiple occasions by both proliferating and post-mitotic cells. Unlike replicating cells, which can employ sister chromatids as a repair template, post-mitotic cells such as adult neurons could...