Analysis of M4 transmembrane domains in NMDA receptor function: a negative allosteric modulator site at the GluN1-M4 is determining the efficiency of neurosteroid modulation
Ionotropic glutamate receptors (iGluRs), like the NMDA receptor, are ligand-gated ion channels. These receptors make up an important part of the mammalian central nervous system (CNS) as they allow rapid excitatory signal transduction. NMDA receptors are built of four structurally identical subunits...
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