Modélisation de l’effet du favipiravir sur la dynamique viro-immunologique de la maladie à virus Ebola et implications pour son évaluation clinique

Modélisation de l’effet du favipiravir sur la dynamique viro-immunologique de la maladie à virus Ebola et implications pour son évaluation clinique

En dépit d’épidémies répétées, il n’existe pas à ce jour de thérapeutique ayant démontré son efficacité dans la maladie à virus Ebola. Sur la base d’expérimentations réalisées chez la souris et le macaque dans le cadre du consortium Reaction!, l’objectif de cette thèse visait à caractériser l’effet...

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Bibliographic Details
Main Author:	Madelain, Vincent
Other Authors:	Sorbonne Paris Cité
Language:	fr en
Published:	2018
Subjects:	Cinétique virale Modèles non linéaires à effets mixtes Nonlinear mixed effects models Pharmacokinetics-pharmacodynamics Viral kinetics Ebola virus disease Favipiravir Antivirals
Online Access:	http://www.theses.fr/2018USPCC049

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