Développement d’approches de modifications ciblées du méthylome dans les cellules mammifères

Développement d’approches de modifications ciblées du méthylome dans les cellules mammifères

La méthylation de l’ADN est une modification épigénétique sur les cytosines des dinucléotides CpG catalysée par les enzymes DNMT. Les cellules cancéreuses présentent des hyperméthylations aberrantes sur les promoteurs de gènes dits suppresseurs de tumeurs, ce qui contribue à leur répression transcri...

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Bibliographic Details
Main Author:	Argüeso Lleida, Andrea
Other Authors:	Strasbourg
Language:	en
Published:	2018
Subjects:	Méthylation de l’ADN Cancer Édition de l’épigénome SERPINB5 TALE DCas9 DNA methylation Epigenome editing 572.8 616.99
Online Access:	http://www.theses.fr/2018STRAJ068

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