Méthodes statistiques pour les essais de phase I/II de thérapies moléculaires ciblées en cancérologie

Méthodes statistiques pour les essais de phase I/II de thérapies moléculaires ciblées en cancérologie

Les essais cliniques de phase I en cancérologie permettent d’identifier la dose optimale (DO), définie comme la dose maximale tolérée (DMT). Les approches conventionnelles de recherche de dose reposent uniquement sur les événements de toxicité observés au cours du premier cycle de traitement. Le dév...

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Bibliographic Details
Main Author:	Altzerinakou, Maria Athina
Other Authors:	Paris Saclay
Language:	fr
Published:	2018
Subjects:	Dose optimale Mesures de biomarqueur Modèles conjoints Recherche de dose Thérapies moléculaires ciblées Toxicité cumulative Biomarker measurements Cumulative toxicity Dose-Finding Joint modeling Molecularly targeted agents Optimal dose
Online Access:	http://www.theses.fr/2018SACLS375/document

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