Generation of high drug loading amorphous solid dispersions by different manufacturing processes

Generation of high drug loading amorphous solid dispersions by different manufacturing processes

La principale difficulté lors de l'administration orale d'un ingrédient pharmaceutique actif (API) est de garantir que la dose clinique de l’API sera dissoute dans le volume disponible de liquides gastro-intestinaux. Toutefois, environ 40% des API sur le marché et près de 90% des molé...

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Bibliographic Details
Main Author:	Lins de Azevedo Costa, Bhianca
Other Authors:	Ecole nationale des Mines d'Albi-Carmaux
Language:	en
Published:	2018
Subjects:	Dispersions solides amorphes Séchage par atomisation Extrusion à chaud Amélioration de la solubilité Diagramme de phase Libération de principe actif Efavirenz Soluplus Amorphous solid dispersions Spray drying Hot-melt extrusion Solubility enhancement Phase diagram Drug release 620
Online Access:	http://www.theses.fr/2018EMAC0012/document

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