Identification des gènes impliqués dans la coopération oncogénique avec BCR-ABL1 dans la Leucémie Myéloïde Chronique

Identification des gènes impliqués dans la coopération oncogénique avec BCR-ABL1 dans la Leucémie Myéloïde Chronique

La leucémie myéloïde chronique (LMC) a été le premier cancer humain associé à une anomalie chromosomique : le chromosome de Philadelphie. Le gène de fusion BCR-ABL1 résultant code pour une tyrosine kinase ayant une activité dérégulée. Les inhibiteurs de tyrosine kinase (ITKs), qui inactivent la prot...

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Bibliographic Details
Main Author:	Rousseau, Emilie
Other Authors:	Bordeaux
Language:	fr
Published:	2018
Subjects:	LMC Modèle cellulaire humain CRISPR-Cas9 BCR-ABL1 Transformation tumorale P53 CML Human cellular model Tumoral transformation
Online Access:	http://www.theses.fr/2018BORD0281

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