Evaluation préclinique d'une nouvelle combinaison thérapeutique associant l'irinotécan à un inhibiteur de mTOR pour le traitement des tumeurs coliques

Evaluation préclinique d'une nouvelle combinaison thérapeutique associant l'irinotécan à un inhibiteur de mTOR pour le traitement des tumeurs coliques

Positionnée en aval des voies PI3K/AKT et RAS/MAPK, la protéine kinase mTOR joue un rôle déterminant dans le développement et la progression tumorale des cancers colorectaux où elle est fortement surexprimée. Par ailleurs, les cancers colorectaux comme toutes les tumeurs solides, ont un microenviron...

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Bibliographic Details
Main Author:	Reita, Damien
Other Authors:	Strasbourg
Language:	fr
Published:	2017
Subjects:	Cancer colorectaux MTOR HIF-1α HIF-2α Irinotécan Inhibiteurs de mTOR AZD2014 Colon cancer Irinotecan MTOR inibitors 572.8 615.7
Online Access:	http://www.theses.fr/2017STRAJ071

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