Insights on type I IFN signaling and regulation : studies of disease-associated TYK2 variants and of the negative regulators USP18/ISG15

Insights on type I IFN signaling and regulation : studies of disease-associated TYK2 variants and of the negative regulators USP18/ISG15

L'action ubiquitaire de l'interféron de type I (IFN- alpha/beta , ici IFN) dans la physiologie et la pathologie est aujourd'hui certaine. Une réponse dérégulée à l'IFN peut entraîner des interféronopathies ou des maladies auto-immunes. Dans mon travail de thèse j'ai étudié t...

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Bibliographic Details
Main Author:	Li, Zhi
Other Authors:	Paris 6
Language:	en
Published:	2017
Subjects:	Interferon de type I Janus kinase Maladies auto-Immunes Polymorphisme nucleotidique simple Usp18 Isg15 Type I interferon Auto-immune disease 571.9
Online Access:	http://www.theses.fr/2017PA066437/document

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