Microenvironnement médullaire et résistance des LAM FLT3-ITD aux inhibiteurs de tyrosine kinase : Rôle pivot du récepteur TAM AXL

Microenvironnement médullaire et résistance des LAM FLT3-ITD aux inhibiteurs de tyrosine kinase : Rôle pivot du récepteur TAM AXL

La duplication interne en tandem au sein du gène du Fms-like tyrosine kinase 3 (FLT3) est l’une des mutations les plus fréquemment observées dans les leucémies aiguës myéloblastiques (LAM). Elle est corrélée à un mauvais pronostic. Des inhibiteurs de tyrosine kinase anti-FLT3 (FLT3-ITK) sont en cour...

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Bibliographic Details
Main Author:	Dumas, Pierre-Yves
Other Authors:	Bordeaux
Language:	fr
Published:	2017
Subjects:	Leucémie aiguë myéloblastique FLT3-ITD AXL Microenvironnement Hypoxie Cytokines STAT5 Acute myeloid leukemia Microenvironment Hypoxia
Online Access:	http://www.theses.fr/2017BORD0675/document

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