Induction de la voie IFN/STAT1 dans le cancer du sein sous chimiothérapie : étude mécanistique

Induction de la voie IFN/STAT1 dans le cancer du sein sous chimiothérapie : étude mécanistique

Le cancer du sein est le cancer le plus fréquent chez la femme. Malgré la chimiothérapie, certaines patientes ont une réponse incomplète et récidivent quelques années plus tard. Le but de ce travail était d’étudier les mécanismes moléculaires mis en place par les cellules tumorales en réponse aux tr...

Full description

Bibliographic Details
Main Author:	Gaston, Julie
Other Authors:	Sorbonne Paris Cité
Language:	fr
Published:	2016
Subjects:	Cancer du sein PDX Chimiothérapie Récidive Interféron STING STAT1 Breast cancer Chemotherapy Recurrence Interferon 611.018 1
Online Access:	http://www.theses.fr/2016USPCB041/document

Similar Items

Caractérisation des cellules souches cancéreuses des sous types luminaux dans le cancer du sein
by: Nguyen, Tien Tuan
Published: (2013)

Etude des altérations moléculaires et évaluation de nouvelles thérapies ciblées dans les cancers du sein triple-négatifs
by: Hatem, Rana
Published: (2015)

The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma
by: Ying Liu, et al.
Published: (2018-12-01)

Potentiel thérapeutique et mécanismes d'action du resvératrol dans les déficits héréditaires de la chaîne respiratoire
by: Lopes Costa, Alexandra
Published: (2014)

STING-Mediated Autophagy Is Protective against H<sub>2</sub>O<sub>2</sub>-Induced Cell Death
by: Amar Abdullah, et al.
Published: (2020-09-01)

Progesterone receptor promotes degradation of STAT2 to inhibit the interferon response in breast cancer
by: Katherine R. Walter, et al.
Published: (2020-01-01)

HBsAg Dampened STING Associated Activation of NK Cells in HBeAg-Negative CHB Patients
by: Bingqing Zheng, et al.
Published: (2021-07-01)

Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels
by: T. Galbo, et al.
Published: (2010-04-01)

Identifizierung und Charakterisierung neuer Typ-1-Interferonopathie-assoziierter Gene
by: König, Nadja
Published: (2017)

Étude de l'implication de la régulation hypoxique de la furine dans la progression tumorale
by: Grandmont, Sébastien
Published: (2006)

Docetaxel Enhances the Expression of STING Protein in PC3 Cells, and cGAMP Attenuates this Effect
by: Shaghayegh Salimi, et al.
Published: (2020-11-01)

IFN signaling: how a non-canonical model led to the development of IFN mimetics
by: Howard M Johnson, et al.
Published: (2013-07-01)

Targeting IFN/STAT1 Pathway as a Promising Strategy to Overcome Radioresistance
by: Liu S, et al.
Published: (2020-06-01)

Checkpoint Kinase 1 (Chk1) inhibition fails to activate the Stimulator of Interferon Genes (STING) innate immune signalling in a human coculture cancer system
by: Teresa Brooks, et al.
Published: (2021-06-01)

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
by: Juyan Zheng, et al.
Published: (2020-08-01)

In Vitro Effects of Sulforaphane on Interferon-Driven Inflammation and Exploratory Evaluation in Two Healthy Volunteers
by: Elena Genova, et al.
Published: (2021-06-01)

Study of the lysosomal trafficking of cystinosin and its role in the mTORC1 pathway
by: Andrzejewska, Zuzanna
Published: (2013)

STAT2 Limits Host Species Specificity of Human Metapneumovirus
by: Meredith C. Rogers, et al.
Published: (2020-07-01)

The STING-IFN-β-Dependent Axis Is Markedly Low in Patients with Relapsing-Remitting Multiple Sclerosis
by: Lars Masanneck, et al.
Published: (2020-12-01)

Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway
by: Kai Wang, et al.
Published: (2019-11-01)

Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer
by: Natalia Paez Arango, et al.
Published: (2017-08-01)

Molekulare Determinanten zur sequenzspezifischen DNA-Bindung des Transkriptionsfaktors STAT1
by: Hüntelmann, Bettina
Published: (2018)

A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma
by: Zhenyang Liu, et al.
Published: (2020-06-01)

The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling
by: Bindu Raghavan, et al.
Published: (2014-04-01)

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response
by: Abdul S. Qadir, et al.
Published: (2017-03-01)

Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer
by: Arjan Kol, et al.
Published: (2021-01-01)

Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
by: Olivia K. Provance, et al.
Published: (2019-05-01)

The Combination of IFN β and TNF Induces an Antiviral and Immunoregulatory Program via Non-Canonical Pathways Involving STAT2 and IRF9
by: Mélissa K. Mariani, et al.
Published: (2019-08-01)

Faisabilité d'une intervention préventive de l'insomnie chez des femmes traitées en chimiothérapie pour un cancer du sein
by: Marion, Louis-Philippe
Published: (2018)

TRIM21 Aggravates Herpes Simplex Virus Epithelial Keratitis by Attenuating STING-IRF3-Mediated Type I Interferon Signaling
by: Tianchang Tan, et al.
Published: (2020-04-01)

Manipulation of JAK/STAT Signalling by High-Risk HPVs: Potential Therapeutic Targets for HPV-Associated Malignancies
by: Ethan L. Morgan, et al.
Published: (2020-09-01)

The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
by: Lavinia Rech, et al.
Published: (2021-07-01)

Pulmonary Involvement in a Mouse Model of Sjögren’s Syndrome Induced by STING Activation
by: Joanna Papinska, et al.
Published: (2020-06-01)

Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner
by: Jinu Abraham, et al.
Published: (2020-07-01)

The importance of homotypic interactions of unphosphorylated STAT proteins in cytokine-induced signal transduction
by: Menon, Priyanka Rajeev
Published: (2021)

Impact of Toxoplasma gondii on STAT1 activity and epigenetic regulation during IFN-γ signaling of its host cell
by: Nast, Roswitha
Published: (2018)

Cytokines and STATs in liver fibrosis
by: Xiaoni eKong, et al.
Published: (2012-04-01)

Nouveaux rôles du complexe CCR4-NOT dans le contrôle de l'expression des gènes eucaryotes
by: Chapat, Clément
Published: (2013)

Variantes en los factores de transcripción para IFNγ, TBET, STAT1, STAT4 y HLX, y el riesgo de desarrollar tuberculosis pulmonar en un estudio de casos y controles de una población colombiana
by: María Dulfary Sánchez, et al.
Published: (2013-06-01)

Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2
by: Elisa Fanunza, et al.
Published: (2021-01-01)