Modeling C9ORF72 loss-of-function : a knockdown mouse model

Modeling C9ORF72 loss-of-function : a knockdown mouse model

Les démences frontotemporales (DFT) et la sclérose latérale amyotrophique (SLA) sont deux maladies neurodégénératives dévastatrices. La mutation du gène C9ORF72 a été identifiée comme la cause commune la plus fréquente de ces deux pathologies (c9FTD/ALS). Plusieurs hypothèses pourraient expliquer le...

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Bibliographic Details
Main Author:	Lopez-Herdoiza, Maria Belen
Other Authors:	Paris 6
Language:	en
Published:	2016
Subjects:	C9orf72 Sclérose latérale amyotrophique Démence frontotemporale Modèle murin Caractérisation comportementale Agrégats protéiques C9orf72 loss of function Altered autophagy Amyotrophic lateral sclerosis 616.8
Online Access:	http://www.theses.fr/2016PA066239/document

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