Acides aminés et cancer : LAT1, un transporteur essentiel à l’activité mTORC1 et la croissance tumorale

Acides aminés et cancer : LAT1, un transporteur essentiel à l’activité mTORC1 et la croissance tumorale

Dans le but de maintenir leur métabolisme et leur prolifération exacerbée, les tumeurs sont dépendantes d’un apport accru en acides aminés. Afin d'optimiser cet apport, les tumeurs surexpriment certains transporteurs clés tels que l'hétérodimère multifonctionnel CD98/LAT1. CD98 (SLC3A2) ag...

Full description

Bibliographic Details
Main Author:	Cormerais, Yann
Other Authors:	Nice
Language:	fr
Published:	2016
Subjects:	Stress nutritif Acides aminés LAT1 CD98 Transporteur membranaire Pharmacologie MTORC1 Prolifération Nutrient Stress Amino acids Membrane transporter Pharmacology Cancer
Online Access:	http://www.theses.fr/2016NICE4047/document

Similar Items

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer
by: Yann Cormerais, et al.
Published: (2021-12-01)

Pathological Consequences of Hepatic mTORC1 Dysregulation
by: Chun-Seok Cho, et al.
Published: (2020-08-01)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
by: Jin Young Yang, et al.
Published: (2019-06-01)

Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors
by: Satish Kantipudi, et al.
Published: (2021-05-01)

RORα is critical for mTORC1 activity in T cell-mediated colitis
by: Xinxin Chi, et al.
Published: (2021-09-01)

Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1
by: Asara, J.M, et al.
Published: (2022)

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors
by: Justin A. De Leon, et al.
Published: (2017-11-01)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
by: Linqing Miao, et al.
Published: (2016-03-01)

LATS1 Is a Mediator of Melanogenesis in Response to Oxidative Stress and Regulator of Melanoma Growth
by: Urszula Kazimierczak, et al.
Published: (2021-03-01)

mTORC1 signaling in hepatic lipid metabolism
by: Jinbo Han, et al.
Published: (2017-04-01)

The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
by: Stephanie A. Fernandes, et al.
Published: (2021-08-01)

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells
by: Jun-Kyu Byun, et al.
Published: (2017-07-01)

Recent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1
by: Liufeng Zheng, et al.
Published: (2016-09-01)

Modulation of mTORC1 Signaling Pathway by HIV-1
by: Burkitkan Akbay, et al.
Published: (2020-04-01)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
by: Marcelle C. Ribeiro, et al.
Published: (2018-07-01)

The amelioration of metabolic disorders in early stage diabetic rats by resveratrol is associated with mTORC1 regulation
by: Jeng-Yuan Yao, et al.
Published: (2015-10-01)

Pharmacologic inhibition of mTORC1 mimics dietary protein restriction in a mouse model of lactation
by: Virginia L. Pszczolkowski, et al.
Published: (2020-06-01)

Association analysis between SNPs in LATS1 and LATS2 and non-cardia gastric cancer
by: Li-cong Ma, et al.
Published: (2020-05-01)

Regulation of mTORC1 by Upstream Stimuli
by: Chase H. Melick, et al.
Published: (2020-08-01)

Role of LATS1/2 in Prognosis of Advanced Gastric Cancer and Its Relationship With the Tumor Immune Microenvironment
by: Yixian Guo, et al.
Published: (2020-08-01)

A critical role for mTORC1 in erythropoiesis and anemia
by: Zachary A Knight, et al.
Published: (2014-09-01)

TFEB-mTORC1 feedback loop in metabolism and cancer
by: Chiara Di Malta, et al.
Published: (2017-10-01)

Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation
by: Lili Quan, et al.
Published: (2020-11-01)

Characterisation of L-Type Amino Acid Transporter 1 (LAT1) Expression in Human Skeletal Muscle by Immunofluorescent Microscopy
by: Nathan Hodson, et al.
Published: (2017-12-01)

A two-pore channel protein required for regulating mTORC1 activity on starvation
by: Fu-Sheng Chang, et al.
Published: (2020-01-01)

Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells
by: Jose A. Sandoval, et al.
Published: (2020-11-01)

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4
by: Yeonwoo Park, et al.
Published: (2017-05-01)

Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin
by: Se-Kyeong Jang, et al.
Published: (2021-07-01)

Locally Produced IGF-1 Promotes Hypertrophy of the Ligamentum Flavum via the mTORC1 Signaling Pathway
by: Bin Yan, et al.
Published: (2018-07-01)

Berberine Protects Mice Against Dextran Sulfate Sodium-Induced Colitis by Activating mTORC1 Pathway
by: Qingjun Li, et al.
Published: (2019-07-01)

Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells
by: Wenxing Chen, et al.
Published: (2017-01-01)

IL-36β Promotes CD8+ T Cell Activation and Antitumor Immune Responses by Activating mTORC1
by: Xin Zhao, et al.
Published: (2019-08-01)

mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer
by: Karen Griselda de la Cruz López, et al.
Published: (2019-12-01)

Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage
by: Wuping Yang, et al.
Published: (2019-03-01)

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
by: Lan eYe, et al.
Published: (2012-09-01)

Decreased expression of LATS1 is correlated with the progression and prognosis of glioma
by: Ji Tianhai, et al.
Published: (2012-08-01)

Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer
by: Qirong Geng, et al.
Published: (2017-04-01)

Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target
by: Claudia Buerger
Published: (2018-11-01)

SREBP: A Key Effector of mTORC1 Signaling in Metabolism and Cancer
by: Yecies, Jessica
Published: (2013)

The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2
by: Satish Kantipudi, et al.
Published: (2020-10-01)