Synthèse d'inhibiteurs de l'interaction entre la protéine à domaine PDZ, PSD-95 et le récepteur de la sérotoninte 5-HT2A pour le traitement des douleurs neuropathiques

Synthèse d'inhibiteurs de l'interaction entre la protéine à domaine PDZ, PSD-95 et le récepteur de la sérotoninte 5-HT2A pour le traitement des douleurs neuropathiques

Les protéines à domaines PDZ sont impliquées dans des interactions protéine-protéine (IPP) et participent aux transports de signaux impliqués dans de nombreuses pathologies (cancer, mucoviscidose, douleur,…). L’interruption de l’interaction entre la protéine à domaine PDZ, PSD-95, et le récepteur de...

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Bibliographic Details
Main Author:	Vallon, Gary
Other Authors:	Clermont-Ferrand 2
Language:	fr
Published:	2016
Subjects:	Protéines à domaines PDZ Récepteur de la sérotonine 5-HT2A Relation Structure Activité Fragment-based drug design Modélisation moléculaire Synthèse organique multi-étapes Douleur PDZ domains proteins Serotonin receptor 5-HT2A Structure Activity Relationship Molecular modeling Organic multi-step synthesis Pain
Online Access:	http://www.theses.fr/2016CLF22664

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