Regulation of DNA methylation by DNA glycosylases MBD4 and TDG

Regulation of DNA methylation by DNA glycosylases MBD4 and TDG

Chez les mammifères, la méthylation est une marque épigénétique ciblant la cytosine principalement dans un contexte CpG pour produire une 5mC. 5mC est très sensible à une déamination spontanée ou enzymatique, conduisant à la formation d'un mésappariement G/T. La 5mCpeut également être oxydée po...

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Bibliographic Details
Main Author:	Ibrahim, Abdulkhaleg
Other Authors:	Strasbourg
Language:	en
Published:	2015
Subjects:	Déméthylation MBD4 TGD Glycosylase/lyase Rétro-éléments Oxydation Protéines de réparation Demethylation TDG Glycosylases Retro-elements Oxidation Mismatch repair 572.8
Online Access:	http://www.theses.fr/2015STRAJ019/document

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