Rôle de la protéine Cdk5 en réponse aux dommages de l’ADN : implications dans les points de contrôle S et G2/M

Rôle de la protéine Cdk5 en réponse aux dommages de l’ADN : implications dans les points de contrôle S et G2/M

La kinase dépendante des cyclines 5 (Cdk5) est un facteur de sensibilité aux inhibiteurs de PARP et aux rayonnements ionisants (RI), elle est nécessaire pour le point de contrôle du cycle cellulaire en phase S. Cependant, elle n’est pas directement impliquée dans la réparation des cassures de brin d...

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Bibliographic Details
Main Author:	Chiker, Sara
Other Authors:	Paris 11
Language:	fr
Published:	2015
Subjects:	Cdk5 Hydroxyurée Stress réplicatif PARP-1 Rayonnements ionisants Hydroxyurea Replication stress Lonizing Radiation
Online Access:	http://www.theses.fr/2015PA11T001/document

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