Design, synthèse et évaluation biologique de mimes du paclitaxel dérivés de la proline

Design, synthèse et évaluation biologique de mimes du paclitaxel dérivés de la proline

Parmi les nombreux agents thérapeutiques utilisés en oncologie, le paclitaxel (Taxol®) est sans doute celui qui a suscité le plus d'intérêt. Il est utilisé en clinique pour le traitement des cancers de l'ovaire, du sein et des poumons. Il agit comme poison du fuseau mitotique en favorisant...

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Bibliographic Details
Main Author:	Lamotte, Yann
Other Authors:	Paris 6
Language:	fr en
Published:	2015
Subjects:	Paclitaxel Taxol Tubuline Microtubules Cancer Proline Mime Fragment Cyclotriproline Mimic 540
Online Access:	http://www.theses.fr/2015PA066608/document

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