Etude in vivo du rôle de la région régulatrice en 3' du locus des chaînes lourdes d'immunoglobulines dans les réactions inflammatoires et la lymphomagenèse B

Etude in vivo du rôle de la région régulatrice en 3' du locus des chaînes lourdes d'immunoglobulines dans les réactions inflammatoires et la lymphomagenèse B

La maturation lymphocytaire B est sous le contrôle des éléments cis-régulateurs des gènes d’Ig. Les quatre activateurs transcriptionnels (hs3a, hs1,2, hs3b et hs4) de la région régulatrice en 3’ du locus IgH (3’RR) murin sont les éléments clés pour les hypermutations somatiques (SHM) et les recombin...

Full description

Bibliographic Details
Main Author:	Saad, Faten
Other Authors:	Limoges
Language:	fr
Published:	2015
Subjects:	Région régulatrice IgH 3'RR Souris Knock-out Pristane Inflammation Cytokines Souris Igλ-Myc Lymphome B IgH 3'regulatory region Knock-out mice B-cells lymphomas Oncogene Igλ-Myc 610
Online Access:	http://www.theses.fr/2015LIMO0030/document

Similar Items

Eléments cis-régulateurs du locus IgH et lymphomagenèse B
by: Ghazzaui, Nour
Published: (2018)

Mouse Models of c-myc Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis
by: Melissa Ferrad, et al.
Published: (2020-07-01)

Modulation of the 3'IgH Regulatory Region (3'IgH RR), a prospective in vitro screening tool for identifying potential immunotoxicants
by: Henseler, Rebecca Anne
Published: (2007)

Etude du rôle de la région régulatrice en 3' du locus IgH au cours du développement lymphocytaire B normal et pathologique
by: Saintamand, Alexis
Published: (2016)

Etude des voies de réparation des cassures double brin de l'ADN lors de la recombinaison suicide du locus IgH en physiologie normale et pathologie du lymphocyte B
by: Boutouil, Hend
Published: (2018)

Hypermutation somatique dans les cellules B normales et pathologiques : éléments cis-régulateurs et facteurs nucléaires impliqués
by: Martin, Ophélie Alyssa
Published: (2018)

VH Replacement Footprint Analyser-I (VHRFA-I), a Java based Computer Program for Analyses of Immunoglobulin Heavy Chain Genes and Potential VH Replacement Products in Human and Mouse
by: Lin eHuang, et al.
Published: (2014-02-01)

Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires
by: Yang Yang, et al.
Published: (2015-09-01)

Silencing immunoglobulin gene enhancers as a potential treatment strategy for multiple myeloma
by: Toman, Inka
Published: (2009)

Switch Canonique en Cis ou Trans et Recombinaisons Suicides du Locus IgH
by: Dalloul, Iman
Published: (2018)

Genomic architecture may influence recurrent chromosomal translocation frequency in the Igh locus
by: Amy L Kenter, et al.
Published: (2013-12-01)

Misregulation of the IgH Locus in Thymocytes
by: Gita Kumari, et al.
Published: (2018-11-01)

Mécanistique de la commutation de classe des immunoglobulines et production de classes rares (IgE, IgA2 et pseudo-IgG)
by: Dalloul, Zeinab
Published: (2018)

PCR und Fluoreszenz-DNA-Fragment-Analyse zum Nachweis einer monoklonalen B-Zell-Population zur Diagnostik der kutanen B-Zell Lymphome (CBCL)
by: Marchwat, Maren
Published: (2004)

Analyse de la fonction de la région de contrôle du locus des chaînes lourdes des immunoglobulines au cours du développement des lymphocytes B
by: Braikia, Fatima-Zohra
Published: (2015)

Immunoglobulin genes and T-cell receptors as molecular markers in children with acute lymphoblastic leukaemia
by: Lazić Jelena, et al.
Published: (2009-01-01)

Applicability of PCR-based clonality assay in dogs with multicentric lymphoma
by: V. Nowosh, et al.

Monoclonal immunoglobulin heavy chain gene rearrangement in Fuchs’ uveitis
by: Hisae Nakahara, et al.
Published: (2018-03-01)

Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells
by: Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO
Published: (2014-09-01)

Elucidating Mechanisms of IgH Class Switch Recombination Involving Switch Regions and Double Strand Break Joining
by: Zhang, Tingting
Published: (2013)

Long-Range Control of Class Switch Recombination by Transcriptional Regulatory Elements
by: Audrey Dauba, et al.
Published: (2021-09-01)

Functional associations between polymorphic regions of the human 3′IgH locus and COVID-19 disease
by: Borghetti, A., et al.
Published: (2022)

Identification of DNA cleavage- and recombination-specific hnRNP co-factors for activation-induced cytidine deaminase
by: Hu, Wenjun
Published: (2015)

Rôle des ligands du récepteur au CNTF dans le développement et étude de la signalisation induite par ces cytokines dans des modèles cellulaires de cancer
by: Guilhot, Florence
Published: (2016)

Etude de l'effet des modulations de l'expression des métalloprotéases et de leurs inhibiteurs dans la réaction bronchique aux aéroallergènes.
by: Guéders, Maud
Published: (2008)

Participação do gene Slc11a1 na modulação da resposta imune na artrite induzida por pristane em camundongos selecionados para resposta inflamatória aguda.
by: Mara Adriana Corrêa
Published: (2015)

Participação do gene Slc11a1 na modulação da resposta imune na artrite induzida por pristane em camundongos selecionados para resposta inflamatória aguda.
by: Corrêa, Mara Adriana
Published: (2015)

The effect of lipoprotein-associated phospholipase A<sub>2</sub> deficiency on pulmonary allergic responses in <it>aspergillus fumigatus</it> sensitized mice
by: Jiang Zhilong, et al.
Published: (2012-11-01)

RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase
by: Yin, Ziwei
Published: (2020)

Detection of new allotypic variants of bovine antibody λ-light chain and IgG-heavy chain constant regions
by: Aboelhassan, Dalia
Published: (2012)

Observation on frequency & clinico-pathological significance of various cytogenetic risk groups in multiple myeloma: an experience from India
by: Pratibha S Kadam Amare, et al.
Published: (2016-01-01)

Immunomodulatory Effect of Agave tequilana Evaluated on an Autoimmunity Like-SLE Model Induced in Balb/c Mice with Pristane
by: Zúlima Jannette Gutiérrez Nava, et al.
Published: (2017-05-01)

<em>Bryophyllum pinnatum</em> leaves ethanol extract inhibit maturation and promote apoptosis of systemic lupus erythematosus BALB/c mice B cells
by: Kusworini Handono, et al.
Published: (2018-02-01)

Transfer of Maternal Anti-Microbial Immunity to HIV-Exposed Uninfected Newborns
by: Bahaa Abu Raya, et al.
Published: (2016-08-01)

B cell subsets in atherosclerosis
by: Heather M. Perry, et al.
Published: (2012-12-01)

Decreased IgA+ B Cells Population and IgA, IgG, IgM Contents of the Cecal Tonsil Induced by Dietary High Fluorine in Broilers
by: Kangping Wang, et al.
Published: (2013-05-01)

Evaluation of immunomodulatory effects of zearalenone in mice
by: Mohammad Rafiqul Islam, et al.
Published: (2017-01-01)

Novel immunomodulatory effects of phytanic acid and its related substances in mice
by: Tomonori Nakanishi, et al.
Published: (2016-03-01)

B Cell Intrinsic Mechanisms Constraining IgE Memory
by: Brice Laffleur, et al.
Published: (2017-11-01)

Zonificación molecular de yacimientos de edad eoceno y mioceno al norte de la cuenca del lago de Maracaibo
by: Jhoan José Urdaneta
Published: (2019-08-01)

Cannot write session to /tmp/vufind_sessions/sess_7oo10ci6imn8rk6enaet9h579q