Etude de stratégies innovantes pour augmenter l'efficacité antitumorale de ligands synthétiques de TRAIL-R2 et CD40

Etude de stratégies innovantes pour augmenter l'efficacité antitumorale de ligands synthétiques de TRAIL-R2 et CD40

TRAIL (TNF-Related Apoptosis Inducing Ligand) et CD40 Ligand, membre de la superfamille (SF) du TNF (Tumor Necrosis Factor) apparaissent comme des cibles attractives pour la thérapie ciblée du cancer. Une caractéristique commune des membres de la SF-TNF est la structure homotrimérique du ligand qui...

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Bibliographic Details
Main Author:	Chekkat, Neïla
Other Authors:	Strasbourg
Language:	fr
Published:	2014
Subjects:	Cancer TRAIL CD40 Apoptose Ligands peptidiques multivalents Oligomérisation Apoptosis Multivalent peptidic ligands Oligomerization 572.4 571.96 616.99
Online Access:	http://www.theses.fr/2014STRAJ043/document

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