Vectorisation de molécules thérapeutiques aux tissus cérébraux
La présence de la glycoprotéine P (P-gp) dans la barrière hémato-encéphalique (BHE) conduit à l’échec de nombreuses thérapies ciblant le système nerveux central (SNC). Cependant la P-gp protège aussi le cerveau contre des composés nocifs, essentiellement lipophiles, endogènes et exogènes susceptible...
Main Author: | Nieto Montesinos, Rita Milagros |
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Other Authors: | Besançon |
Language: | en |
Published: |
2014
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Subjects: | |
Online Access: | http://www.theses.fr/2014BESA3002/document |
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