Contribution à la synthèse totale de la céphalotaxine

Contribution à la synthèse totale de la céphalotaxine

Depuis plus de 40 ans des chimistes se sont intéressés à l’extraction, à l’activité biologique et à la synthèse de l’homoharringtonine (HHT), un ester naturel de la céphalotaxine, qui est un puissant antileucémique utilisé pour le traitement des leucémies résistantes aux inhibiteurs de tyrosine kina...

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Bibliographic Details
Main Author:	Quteishat, Laith
Other Authors:	Paris 11
Language:	fr
Published:	2013
Subjects:	Alcaloïdes Céphalotaxine Activité antileucémique Synthèse totale Complexes arène chrome carbonyle Cyclisation 3-benzazépine Nitrile Réaction de Heck Solvolyse Processus éco-compatible Micro-ondes Alkaloids Cephalotaxine Antileukemic activity Total synthesis Chromium carbonyl complexes Cyclization 3-benzazepine Imide Heck reaction Solvolysis Sustainable process Micro-waves
Online Access:	http://www.theses.fr/2013PA114846/document

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