Etude du rôle de la traduction dans les leucémies aigues myéloïdes : les voies mTORC1, LKB1/AMPK et la sérine-thréonine kinase PIM-2

Etude du rôle de la traduction dans les leucémies aigues myéloïdes : les voies mTORC1, LKB1/AMPK et la sérine-thréonine kinase PIM-2

Les leucémies aigues myéloïdes (LAM) sont des hémopathies malignes de mauvais pronostic dont les thérapies actuelles ne permettent d’obtenir des taux de survie à 5 ans chez les adultes que d’environ 40%. Par conséquent, il est nécessaire d’approfondir nos connaissances concernant les mécanismes d’on...

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Bibliographic Details
Main Author:	Green, Alexa Samantha
Other Authors:	Paris 5
Language:	fr en
Published:	2013
Subjects:	LAM MTORC1 LKB1/AMPK Metformine Rapamycine SGI-1776 EIF4E Traduction cap-dépendante Pim2 Flt3-ITD AML Metformin Rapamycin Cap-dependant translation 616.994 19 616.15
Online Access:	http://www.theses.fr/2013PA05S019

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